Hi James,
Please refer to the steps below to configure your computer for Office 365:
1. Sign in to the Office 365 portal. In the right pane, under Resources, click Downloads.
2. Under Set up and configure your Office desktop apps, click Set up. The Microsoft Office 365 desktop setup tool starts.
3. Sign in using your user ID.
4. After you have selected the applications you want to configure, click Continue, review the service agreements, and then click I accept to begin installing updates and configuring desktop applications.
You can also find detailed information in the following link:
onlinehelp.microsoft.com/.../ff637594.aspx
In addition, please check the Windows updates to make sure your computer has been up to date.
Moreover, if the issue persists, could you please capture the error messages and posts them here for further troubleshooting?
Thanks,
Nancy Xie